Biofilms, SIBO and the Chronic Illness Connection

fibromyalgia biofilmThis is a bacterial biofilm.

It is a slimy, impenetrable matrix that bacterial colonies create in order to protect themselves from our immune system.

It took a lot of research and trial and error to realize how important this was in ending my health conditions.

As it turned out, once I began clearing this stuff out of my body, everything began to change for me. And quickly.

My name is Jean Stanford and I suffered for a very long time with fibromyalgia/CFS and other autoimmune conditions including IBS, and ulcerative colitis.

It wasn’t until I began learning about biofilm and its role in these type of conditions that things began to dramatically shift.

What I’m about to share with you may not be something that works for everyone who suffers from Fibro & chronic illness, but it sure has helped thousands.

I will spare you the story of my long, 15 year journey as I can imagine you may already understand how horrible it can be.

But during those sick years, I was doing my research. Lots of research.

I ventured down many avenues and took all the ones that showed any sort of promise.

Then I came across a research paper from Cedars Sinai Center in Los Angeles that showed a link between SIBO (small intestinal bacterial overgrowth) and fibromyalgia.

This study revealed that 100% of the people who had fibromyalgia also had SIBO [1]

Another recent study [2] found that out of 40 patients with fibromyalgia, 28 (70%) had intestinal permeability (i.e. leaky gut syndrome). And, incredibly, 12 of the 28 patients with leaky gut showed no gut symptoms.

That was shocking to me. Because almost half of those patients with leaky gut showed absolutely no digestive symptoms.

(Continue reading below to learn more about this study)

This one discovery led me down the path that eventually led me out of my nightmare.

You see, once I began focusing on my gut microbiome, where bacterial overgrowth was happening, everything starting changing for me. And fast!

And when I began connecting these dots, things really began to shift…

Here’s what happened:

SIBO, Biofilms and the Fibromyalgia Connection

sibo fibromyalgiaI began learning ways to eliminate SIBO and quickly realized that the #1 reason that SIBO is so difficult to eliminate is because of biofilm.

As you learned earlier, biofilm is a protective layer that harmful gut bacteria as well as Candida yeast create to protect themselves from our immune system.

Did you know that over 80% of bacterial infections in humans are estimated to involve the formation of bacterial colonies, or biofilms.

It’s also been documented that bacteria protected within biofilms are up to 1,000 times more resistant to antibiotics than if they were free-floating.[3]

Worst of all, bacterial biofilm harbors over 40 different kinds of neurotoxins and cytokines, including ammonia, which are secreted by these pathogenic bacteria, causing all kinds of neurological damage to the body.

Fun Fact #1


And this is just the first problem with biofilms…

Once colonies of yeast & bacteria become overgrown beneath this biofilm, the toxins they secrete can often break down delicate links in the intestinal wall known as “tight junctions”, which are essentially the glue that keeps the intestinal wall together.

Established colonies are known to puncture through these tight junctions allowing organisms and other toxins and undigested food particles to enter the bloodstream.

Leaky Gut Syndrome

The result is something called “Leaky Gut Syndrome”.

Many believe this to be a key in understanding allergies, food sensitivities and why the body goes into an inflammatory response.

The immune system sees these “foreign invaders” entering the bloodstream and mounts an all-out attack.

The only problem is, this attack is continuous. Never ending. The gut is letting in these invaders indefinitely.

Your body is constantly “under attack”. In a continuous state of code red.

That’s when I Finally Found My Solution

I discovered an all-natural substance that proved to be a clear cut winner at breaking down biofilm.

In fact, our body naturally produces them for almost every biochemical process it goes through. These are enzymes.

There are so many different types of enzymes that the body produces, however, we’ve isolated a handful of enzymes which work extremely well at dissolving biofilm.

These exact enzymes have also long been used for their anti-aging, anti-inflammatory, anti-viral and blood cleansing properties for centuries.

These are all-natural, proteolytic enzymes which work quickly and effectively to break down the biofilm barrier in the gut to expose these harmful pathogens.

Once exposed, our immune system can go to work regulating these pathogens.

biofilm life cycle restore 3
How biofilm attacks the body

These natural enzymes went to work and quickly began breaking down years worth of biofilm strongholds within my gut.

I knew this because I actually felt worse before I felt better. I was herxing for the first few days. I felt very fatigued and my body wasn’t very happy.

This can sometimes happen when the body is tasked to process all the toxic material and dead bacteria that is moving out at a rapid rate. It often feels like the cold or flu.

biofilm disruption
How enzymes dissolve biofilm

However, I learned ahead of time that this may potentially happen and I saw it as a good sign that what I was doing was actually working.

It wasn’t until later that I refined my approach by following a specific diet and introducing specialized probiotics to my daily regimen.

The diet was there to help kill off any resilient pathogenic bacteria leftover and the specialized probiotics were used to replenish my gut microbiome with friendly colonies.

In the first couple of weeks I noticed a few improvements with my muscle fatigue. I seemed to have a little bit more stamina and less joint pain.

With each passing week, I was getting stronger and stronger.

I was waking up feeling refreshed from a deep nights rest and my body felt lighter.

The way I describe it to people is that my body felt like a pair of glasses that were caked in mud and the mud had finally washed away revealing a clarity that I had long forgotten.

The strange thing about being chronically ill is that often, you don’t really realize how sick you actually were until you begin to feel better.

And wow did I feel better! I could barely contain my energy. I eventually began to have more energy than I knew what to do with.

It felt like I stepped into a new body. One that was 25 years younger.

Looking back now, it makes perfect sense.

Because, if our bodies are 10x more microbe cells than human cells, then it’s obvious that the focus should be on the microbiome and ensuring it’s in balance.

Modern medicine is beginning to recognize this as well and it is exactly why so much research in the past few years has been centered around the microbiome.

I had to share this discovery with others. I knew it would benefit so many who, like me, were trying to escape this living nightmare.

For the last 15 years, myself along with a few other former patients, have been perfecting and refining this program, which has already helped thousands get back the life they once had.

Here’s How it Works:

Essentially, there are 3 phases:

1. Dissolve/Disrupt the biofilm
2. Eliminate the pathogenic colonies and toxic buildup
3. Restore the gut microbiome with friendly bacterial colonies

I found it must be done in this order or else you’ll be perpetually stuck just trying to get past step 1.


“Much needed relief…”

“I was plagued with digestive discomfort & issues for over half my life and nothing I was doing could make it go away. I started seeing results from Restore 3 almost from day one and it has been such a relief. I love the book and guidelines for what seems to be working extremely well for me right now.”       –Sandra Carr, Texas


*Testimonials are individual accounts. Results may vary.


The Restore 3 Program is a 3-Phase Program that:

Green-Check-Mark-3-21x19 Supports Rapid Biofilm Disruption – So you can see real results fast†.
Green-Check-Mark-3-21x19Clears Out Bacteria & Yeast Buildup – Feel better & have more energy†.
Green-Check-Mark-3-21x19Step-by-Step Guide – Be guided through each step. Know exactly what to do.

Each part of the program was carefully designed according to what actually worked for us. There is no fluff here. It’s been refined down to only a few short steps that anyone can follow and see fast results.


Why Does It Work?

Because each of these ingredients below revealed over and over again to be the clear-cut winners for us. Each ingredient below performs at least one of the following actions†:

Disrupt – Disrupt Pathogenic Biofilm
Remove – Remove Bacterial Pathogens
Replenish – Replenish the Gut Microbiome



Discovery #1: Proteolytic Enzymes – Protease S & Serrapeptase

Often referred to as the super enzyme, Serrapeptase and Protease S are the true workhorses of the biofilm disrupting component of this formulation. Biofilm is mostly made up of protein and sugars. In order to breakdown the tough wall of biofilm, it requires a lot of protein digesting enzymes and Protease & Serrapeptase are among some of the most powerful enzymes currently used [4] . Any biofilm disrupting supplement should have a minimum of 150,000 HUT (Hemoglobin unit on a Tyrosine basis) of activity. We made sure to provide a minimum of 200,000 HUT for our formula.



Discovery #2: Cellulase & Hemicellulase

No biofilm dissolving formula is complete without the use of cellulase and hemicellulase to support the break down of the polysaccharide element of biofilm. Polysaccharide are complex sugars that bind with protein molecules which actually make up most of the biofilm structure. If you don’t have these sugar dissolving compounds, you are missing a critical element to biofilm disruption.



Discovery #3: Glucoamylase & Amylase

Present in saliva, and also secreted by the pancreas, these enzymes serve 2 purposes in Restore 3: To support breakdown of the biofilm barrier by removing the free glucose molecules from biofilm walls, allowing their structures to further break down. And to convert these glucose molecules into immediate, usable energy for the body. Studies [7] have shown glucoamylase may be useful in reducing gas, bloating, heartburn and loss of appetite.[8]



Discovery #4: Lipase

Lipase is an enzyme the body uses to break down fats in food so they can be absorbed in the intestines. Lipase is produced in the pancreas, mouth, and stomach. Lipase isn’t a proteolytic (protein digesting), however it compliments the action that the proteolytic enzymes have by working on leftover fats and carbohydrates both in the intestinal tract and the bloodstream — cleaning up what proteolytics cannot touch.


probiotics fibromyalgia

Discovery #5: Bacillus Coagulans

Much research has been done on Bacillus coagulans in the past 10 years and several recent studies in particular have indicated B. coagulans to be a powerful catalyst in significantly improving abdominal pain and bloating in people with IBS and other related symptoms [9],[10]. B. coagulans is one of the few probiotics that doesn’t require refrigeration and is able to survive the exposure to the acid and bile it encounters in the GI tract while having the unique ability to rapidly colonize once it reaches the intestinal tract. Most probiotic supplements do not go on to colonize the GI tract.



Discovery #6: Bacillus Subtilis

Bacillus subtilis has long been an important part of the traditional Japanese fermented food, Natto, and the consumption of this has been linked to several health benefits. B. subtilis also exists naturally in a healthy human G.I. tract. Just like B. coagulans, it is an extremely hearty, spore forming probiotic that requires no refrigeration and studies indicate its ability to target and colonize and crowd out [11] pathogenic bacteria in the gut, produce protease and amylase enzymes and stimulate the growth of various lactobacillus species of beneficial probiotics. B. subtilis has also been used as an anti-bacterial and anti-fungal agent in industrial and medical applications [12] and at one point was widely used as a broad spectrum antibiotic, which was lost after less costly methods of producing antibiotics were discovered.


Fun Fact #2



Real reviews from real customers…

“It works…”

“For years I would experience sharp, stabbing aches, especially after eating. I would usually have it very bad in the winters for some reason, but this winter has been very minor with only a couple of flare ups compared with almost daily flare ups. I will keep taking as long as it is helping. Thank you.”

-Julie Barnes, NH

*Testimonials are individual accounts. Results may vary.

Sarah Bowman-Restore 3 reviews“I was skeptical…”

“I was hesitant to try this product after many failed attempts at natural remedies for my fibroflares. It was at the constant urging of my best friends mother who had tried Restore 3 with great results. It’s been a long road but I feel I’ve finally been able to get my life back. Thank you Native Formulas.”  -Sarah Bowman, Florida

*Testimonials are individual accounts. Results may vary.

Bruce DeLong-Restore 3 review“Off my meds…”

“I was diagnosed in ’03, which was before anyone even really knew what it was it seemed. The prescriptions for it would rarely help, and left me feeling dizzy and tired. Restore 3 wasn’t the first time I tried natural remedies, but it certainly will be my last because I am simply amazed at the results. It would often feel like a long needle being stabbed through my neck and shoulders and leave me literally incapacitaed, often for days. I now have more mobility and best of all my mind is razor sharp again.” -Bruce D. Sunnyvale, California

*Testimonials are individual accounts. Results may vary.

Gail Powers-Restore 3 reviews“I wake up refreshed and alive…”

“I can’t begin to explain the type of life that I was living while coping with fibromyalgia. Some days I would wake up and just stay in bed for 2 hours. I would keep my coffee maker next to my bed, just to give myself a boost out of bed. Once Restore 3 got to work in my body, the changes were dramatic. I could now practically spring out of bed easily and without all those aches and symptoms. It was unbelievable. A welcomed, strange feeling to feel so good after so many years of feeling so bad. I could actually sleep deeply and wake up refreshed now, every day. Thank god I did this. It was like I was living my life walking around wearing lead clothing that just finally dropped off. I feel like I’ve got a new life.” -Gail Powers, Albany, NY

*Testimonials are individual accounts. Results may vary.


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Frequently Asked Questions:

Can’t find the answer to your question below? Feel free to contact us toll free at (888) 627-5170 or by email at

How much Restore 3 do I need to take per day?

Take 2 capsules up to 4 times per day until your symptoms cease. Our unique formula is designed so that you see immediate results, however, it’s best when taken consistently for a longer-term period. This is because Restore 3 works to disrupt biofilm and fibrin buildup within the body while simultaneously restoring the microbiome with specialized probiotics. Often, people don’t start seeing results until at least 4-6 weeks of regular use*, depending on the severity of their deficiency. *Results may vary

Is Restore 3 safe?

Restore 3 is an all-natural supplement. All of its ingredients are naturally occurring, which means the supplement lacks many of the nasty side effects associated with prescription drugs for fibromyalgia*.

When is the best time to take Restore 3?

We’ve found that the ideal time to take Restore 3 is the first thing in the morning or just before going to bed and on an empty stomach. You’ll want to take Restore 3 at least an hour away from food and with at least a 6 oz. glass of water. If taken with food, the enzymes in Restore 3 will simply work on digesting your food.

What is the Restore 3 Program?

When you join the Restore 3 Program, we send you a bottle once a month until you achieve the results you desire. You can easily cancel your membership at any time by emailing or calling our hotline at (888) 627-5170. We will immediately cancel you and send you an email confirmation of your cancellation as well.

What’s in Restore 3?

Restore 3 is made from the highest quality minerals, enzymes and soil based probiotics. They include a potent blend of Proteases including Serrapeptase & Protease S, Amylase, Cellulase & Hemicellulase, Lipase, EDTA and a 2 Billion CFU blend of Bacillus coagulans and Bacillus subtilis.

Can I take Restore 3 with my current medication?

This is always a question that is best answered by your physician. If you are currently taking anti-coagulant drugs (such as Wafarin), consult a healthcare professional before using this product.

Who makes this supplement?

Restore 3 was carefully crafted and designed by the makers at Native Formulas, LLC – an all natural supplement manufacturer based in California who values its customers’ health first. Feel free to contact us any time at

Do you ship to international addresses?

Yes. Currently we ship to the United States and Canada.

How much does shipping cost?

Shipping and handling is free for all orders and they are shipped USPS First-Class mail.

How do I know this will work for me?

Restore 3 is ideal for people with:

1. Fibromyalgia/CFS/Lyme related symptoms
2. IBS related symptoms
3. SIBO related symptoms
4. Pain associated with physical injury
5. Candida related symptoms

Where is it manufactured?

Restore 3 is manufactured right here in the United States in an FDA-approved facility. Unfortunately, many natural supplements are manufactured in China and other overseas countries, which currently has a poor record for creating safe natural supplements. We are proud to manufacture Restore 3 here in the United States.

You can order Right Here. All you need is a mailing address and your credit card.

How do I cancel?

You can easily cancel your membership at any time by emailing or calling our toll-free hotline at (888) 627-5170. We will immediately cancel you and send you an email confirmation of your cancellation as well.

How long will it take to see results?

It varies for different people. Some people may experience benefits within the first couple of hours of taking Restore 3. In the beginning, initial results may be visible in a few weeks*. Often, people don’t start seeing results until at least 2-3 weeks of regular use, depending on the severity of their deficiency. Also important to note is that diet is a huge part of the Restore 3 Program which is why each purchase comes with the eBook “Restore 3 Handbook” which outlines a 3-step action plan to follow while taking the Restore 3 supplement.

Can I take Restore 3 during pregnancy?

Restore 3 is not recommended during pregnancy or while breastfeeding.

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We accept Visa, MasterCard, American Express and Discover cards. We do not accept personal checks or money orders at this time.

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All orders are typically shipped within 24 hours and it should reach you within 2-5 business days.

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We ship all orders by United States Postal Service First Class Mail. Orders received weekdays before 4:00pm PST will ship same day.

Is it shipped discreetly?

Yes, it comes in a plain manila package that simply bears our name “Native Formulas”.

What is your guarantee?

If you are unsatisfied with your purchase, you may return your whole order within 60 days from the purchase date to receive a refund on your product. Refund is limited to one order per customer, and only one bottle per 30 days or a maximum of two bottles within 60 days of a multiple bottle/bulk order. You must include all bottles, whether opened or not. We do not refund any shipping costs.

Native Formulas
2633 Lincoln Blvd. #118
Santa Monica, Ca. 90405

Refund does not include any shipping and handling charges.

We process refunds as quickly as possible. However, please be advised that it may take up to 14 business days to receive a refund after we have received your return.

The Restore 3 Program
A Complete Enzyme & Probiotic Restoration Program

1-Month Supply

(Good Value)

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1 Month Supply of Restore 3
No automatic shipments.

(Free Shipping)

3 Month Supply

(Great Value)

3-Pack of Restore 3 Save Only $54.69 per Bottle.
No automatic shipments.

(Free Shipping)

Discount Membership

(Best Value)

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Get Restore 3 shipped right to your door each month for only $49/mo. You can cancel anytime.

(Free Shipping)

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Verified by Visa
Comodo Secure
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Bonus Report #1:
Instant Download of “Restore 3 Handbook” eBook

FREE for a limited time only, this “Restore 3 Handbook” eBook, written by former long-time fibro/CFS sufferers, guides you through an easy to follow, 3-Step Action Plan that can help relieve your fibromyalgia quickly. And so much more…


Inside this 67-page eBook, you’ll discover:

  • Our 3-step action plan we used for our success
  • The Top 5 foods you absolutely must avoid
  • How this 1 simple trick can boost energy levels
  • How to dissolve biofilms safely and effectively

This eBook is available to members of the Restore 3 Program and can be downloaded instantly to your computer after joining.






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Instant Download of “47 Proven Tips to Feel Better Fast”

fibromyalgia tips


This Special Bonus Report titled “47 Proven Tips to Feel Better Fast” available for immediate download.

  • The 1 thing you’re likely doing everyday to keep you in the ‘sick-loop’
  • How to safely jump-start this bodily process to give you all-day energy
  • How to use this cheap & abundant natural mineral to help you sleep deeply.
  • The most important thing we make sure to do everyday to ensure vibrant health.


The Restore 3 Special Sale Price of $49.00 Includes:

Green-Check-Mark-3-21x19Free Shipping of the Restore 3 Supplement
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Imagine the life awaiting you…

Where you can wake up fully refreshed, feeling your body and mind clear and sharp, ready and excited to start your new day. Going through your entire day without feeling like you need to take a nap.

Or going to bed at night because you feel sleepy, not burnt out. We remember this life of suffering. Believe us when we say, it’s so much clearer on the other side.

We know you may be skeptical.

Because like thousands of others, you may have been put through a whole host of treatments, pills and who knows what else.

Or simply that there was nothing more your doctor could do for you.

What if this really worked for you? How worth it would it be for you to invest the nominal investment in this program to find out?

We’re so confident in this program that we’re willing to offer you to try it for 60 days and if you’re not satisfied, for any reason, you can return it for a full money-back guarantee.

Now there is a solution.

You simply need to take action and try the Restore 3 Program. Your new life begins today.


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Supporting References:

  1. Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Goebel A, Buhner S, Schedel R, Lochs H, Sprotte G.
  2. A link between irritable bowel syndrome and fibromyalgia may be related to findings on lactulose breath testing M Pimentel, D Wallace, D Hallegua, E Chow, Y Kong, S Park, H C Lin
  3. Rasmussen TB, Givskov M. Int J Med Microbiol. 2006;296 (2–3):149–161. [PubMed]
  4. Biofilms. The hypertextbook. v4.3. 2001
  5. Altered intestinal permeability in patients with primary fibromyalgia and in patients with complex regional pain syndrome. Goebel A, Buhner S, Schedel R, Lochs H, Sprotte G.
  6. Allergy and the gastrointestinal system G Vighi, F Marcucci, L Sensi, G Di Cara, and F Frati
  7. Biofilm-Related Infections: Bridging the Gap between Clinical Management and Fundamental Aspects of Recalcitrance toward Antibiotics David Lebeaux, Jean-Marc Ghigo, and Christophe Beloin
  8. [Fibromyalgic syndrome: new perspectives in rehabilitation and management. A review]. [Article in Italian] Melillo N, Corrado A, Quarta L, D’Onofrio F, Trotta A, Cantatore FP.
  9. The relationship between serum antioxidant vitamins, magnesium levels, and clinical parameters in patients with primary fibromyalgia syndrome Sukran Tastan Sakarya, Yesim Akyol, Abdulkerim Bedir, and Ferhan Canturk
  10. Mucosal Maltase-Glucoamylase Plays a Crucial Role in Starch Digestion and Prandial Glucose Homeostasis of Mice Buford L. Nichols, Roberto Quezada-Calvillo, Claudia C. Robayo-Torres, Zihua Ao, Bruce R. Hamaker, Nancy F. Butte, Juan Marini, Farook Jahoor, and Erwin E. Sterchi
  11. Proteolytic enzymes as an alternative in comparison with nonsteroidal anti-inflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review Heyll U, Münnich U, Senger V.
  12. Bacillus coagulans significantly improved abdominal pain and bloating in patients with IBS.
  13. The Gastrointestinal Microbiome and Musculoskeletal Diseases: A Beneficial Role for Probiotics and Prebiotics Luis Vitetta,1,2,* Samantha Coulson,2 Anthony W. Linnane,1,3 and Henry Butt4
  14. Pilot study: A randomised, double blind, placebo controlled trial of pancrealipase for the treatment of postprandial irritable bowel syndrome-diarrhoea Mary E Money, Jaroslaw Walkowiak, Chris Virgilio, Nicholas J Talley
  15. Self-Organization in High-Density Bacterial Colonies: Efficient Crowd Control HoJung Cho, Henrik Jönsson, Kyle Campbell, Pontus Melke, Joshua W Williams,
  16. The production of antifungal volatiles by Bacillus subtilis P.J. Fiddaman, S. Rossall
    Dr S. Rossall, University of Nottingham School of Agriculture, Sutton Bonington, Loughborough, Leics LE12 5RD, UK